MCTNature Work

Olfaction · connectomes · wine chemistry

NeuroTerroir

Build an aroma profile, follow its signals through a reduced fly olfactory circuit, and challenge the result with pathway silencing and rewired controls.

This is an inspectable teaching experiment.The fly circuit does not taste wine, predict preference, establish quality, or reveal terroir. Its readouts are deliberately modest and labeled.

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Biology and interface assumptions are separated.Documented odor-response candidates feed a small project-defined circuit for visualization. Slider values are relative inputs—not ppm, sensory thresholds, or bottle measurements.

Interactive laboratory

Compose. Propagate. Intervene.

Begin with a teaching profile or move each compound manually. Save two circuit states to compare them, silence one input pathway, or replace the downstream weights with a deterministic rewired control.

Reduced circuit view

ORN input → glomeruli → projection neurons → Kenyon-cell groups → engineered readouts

Reduced fly olfactory circuit activityA layered network visualization whose node brightness reflects the selected aroma inputs and circuit condition. INPUTGLOMERULIPROJECTIONKENYON GROUPSREADOUT estersestersacidfloralearth DM1DM2DC4D/DL5DA2 PN₁PN₂PN₃PN₄PN₅ KC AKC BKC CKC DKC EKC F fruitreadoutfloralreadoutalertreadout
Fruit-esters0
Floral channel0
Alert channel0
Signature energy0

Leading channel

Sample A

No sample saved yet.

Sample B · distance

No sample saved yet.

Read before interpreting

What the model is—and is not

The educational value comes from exposing the translation layer. Every number after the documented odor response is a project decision that can be inspected or challenged.

Documented layer

Candidate odorant responses and named glomerular pathways, with strongest confidence for geosmin through Or56a and DA2.

Constructed layer

A small deterministic PN-to-Kenyon matrix, normalization rule, ethanol gain modifier, and three display readouts. These are not measured fly behavior.

Control layer

An input-free baseline, single-pathway silencing, and seeded rewiring make it possible to ask whether a visible result depends on the intended structure.

No hidden wine score. “Fruit,” “floral,” “alert,” and “signature energy” summarize this interface’s internal state. They do not measure deliciousness, typicity, faults at a sensory threshold, health effects, or human preference.

Mapping register

Where each input enters

Confidence labels apply only to the first biological mapping—not to the downstream teaching circuit.

InputWine contextFly entry used hereConfidenceInterface treatment
GeosminEarthy odor / environmental taint contextOr56a → DA2HighDedicated channel
Ethyl acetateFruity to solvent-like, concentration dependentDM1-led broad ester responseMediumDistributed across DM1/DM2
Isoamyl acetateBanana / pear-drop esterDM2-led ester responseMediumDistributed across DM2/DM1
Acetic acidVolatile acidityIr64a-associated acid pathway / DC4 simplificationMediumAcid channel; no threshold claim
LinaloolFloral terpeneDistributed terpene-sensitive responseProvisionalPooled D / DL5 teaching channel
EthanolFermentation matrix componentNo single receptor assignedDeliberate limitGlobal gain modifier

Open development

Inspect the work behind the work

The research ledger lists every GitHub project under review, every source queue, the non-duplication boundaries, and the claims that still need stronger evidence.

Research ledger

Review code provenance, scientific sources, and mapping confidence.

Open the ledger →

Current milestone

Interactive aroma composition, deterministic propagation, A/B comparison, blind profiles, silencing, and rewired controls.

Next evidence work

Replace provisional pooled pathways with concentration-aware response curves where direct primary evidence supports them.